High Performance Liquid Chromatography
with Mass-Spectrometry

Liquid Chromatograph "Waters" with Photodiode Array
and Mass detector's

High Performance Liquid Chromatography with Mass-Spectrometry is rapidly becoming a fundamental tool for biologists and biochemists in their efforts to characterise of the wide range difficult organic compounds and biological objects. Recent advancements in MS technology and front-end methodologies have greatly popularised its use by researchers for the analysis for identification of protein, RNA, biology active substances, pesticides and polycyclic aromatic hydrocarbons, components of pharmaceutical production etc.

Photodiode Array Detector Waters PDA 996
	Technical characteristic: Spectral resolution 1.2 nm Wavelength range 190-800 nm Photodiode array 512 diodes Min time for read all photodiode array 0,011 s Wavelength accuracy ±1 nm

Mass Detector Waters Micromass ZQ 2000
	Technical characteristic: Sensitivity 1 pg reserpine Mass range z/q 2-2000 Ionisation (ESI) electrospray Ion positive negative Type mass-separator quadrupole Spectral stability mass accuracy to within 0.2 Da over a 24-hour period Type controlled injector valve electronically Control of source gas flow rates digital

Created in collaboration by Waters and Micromass, the Waters ZQ is simply the industry's finest benchtop API single quadrupole. And it takes LC/MS speed, sensitivity and ruggedness to a whole new level. Embedded PC electronics allow faster scan rates to give you more points across narrow peaks, while multi-signal acquisition capability provides more information for the right answer, faster. Better still, the Waters ZQ detector with 2000 amu upper mass limit and comes with the Micromass patented ZSpray LC/MS interfase - the only dual orthogonal sampling interfase available. In addition, the Waters ZQ is part of the Waters single-vendor LC/MS system solution - hardware, software, columns and chemistries - designed to work together for reliability and convenience. Put it all together, and the Waters ZQ mass detector clearly delivers more performance than you have ever experienced from a single quad.

Example of the using HPLC-MS for identification of antibiotics

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